Description
Pagoclone
Product information
IUPAC 2-(7-chloro-1,8-naphthyridin-2-yl)-3-(5-methyl-2-oxohexyl)isoindolin-1-one
Synonyms Pagoclone
CAS 133737-32-3
Formula C23H22ClN3O2
Molecular Weight 407.90 g·mol−1
Purity 99.0 % min.
Formulations A neat solid, Powder
Solubility
- DMF: 30 mg/ml
- DMSO: 25 mg/ml
- Ethanol: 30 mg/ml
- Ethanol:PBS (pH 7.2) (1:2): 0.33 mg/ml
Pagoclone
Pagoclone is a derivative of the cyclopyrrolone family that can be used to treat insomnia. It was produced by a team from France. It belongs to a class of non-benzodiazepines that have similar properties to those used for treating other conditions.
It binds to the binding site of human gamma-aminobutyric acid (GABA) receptors. It is a partial agonist that can be used to treat insomnia by targeting the 1, 2, and 5-containing receptors. It also has a full agonist that can be used to treat other conditions.
Compared to the parent compound, pagoclone has a greater anxiolytic activity and can induce sedation. It is also less effective at reducing the effects of sleep. In contrast, zopiclone can be used at low doses to treat insomnia.
According to David Nutt, a pharmacologist, pagoclone could be a potential base for developing a better social drug by producing positive effects on alcohol, which include sociability and relaxation. However, it can also cause negative effects, such as amnesia, nausea, and liver damage. Its effects can be reversed by the use of flumazenil, which has been used as an overdose antidote for benzodiazepines.
Studies have praised the potential of pagoclone, which was partly financed by Indevus, a company that was looking to develop a drug for treating insomnia. However, the long-term safety of the compound is not known. Based on the studies, it is believed that pagoclone could be abused similarly to diazepam, though it is less likely to cause abuse. Despite this, the development of a commercial version of the drug is still unlikely due to the concerns about abuse.
The toxicological and physiological properties of this compound has not been analyzed. Usage of this Chemical should be for research and forensic purposes only.
WARNING This product is not for human or veterinary use.
This product is only available to persons of 21 years old and above.
Hazard statement(s)
| H302 | Harmful if swallowed |
| H315 | Causes skin irritation |
| H319 | Causes serious eye irritation |
| H332 | Harmful if inhaled |
| H335 | cause respiratory irritation |
| H336 | cause drowsiness or dizziness |
| Precautionary statement(s) | |
| P264 | Wash hands thoroughly after handling |
| P280 | protective gloves/protective clothing/eye protection/face protection |
| P305 + P351 + P338 | IF IN EYES: Rinse cautiously with for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| P337 + P313 | If eye irritation persists: Get medical advice/attention |
| P261 | Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray |
| P271 | Use only outdoors or in a well-ventilated area |
| P304 + P340 | IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing |
| P312 | Call a POISON CENTER or doctor/physician if you feel unwell |
| P403 + P233 | Store in a well-ventilated place. Keep container tightly closed |
| P405 | Store locked up |
| P501 | Dispose of contents/container to a licensed disposal company |
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