What is 1P LSD?

1P-LSD is a naturally occurring hallucinogenic substance found in plants. It was first used as a treatment for alcoholism in the 1970s. It is a potent inhibitor of an important family of trans-receptor sites in the brain and is capable of inducing hallucinations and severe depression in humans in certain experimental conditions. It is also known to cause neurological and behavioral disorders in humans, including severe distress in people suffering from serious psychiatric illnesses such as schizophrenia. For this reason, it has been investigated as a potential treatment for a variety of psychological conditions. In recent years, it has become popular as an alternative medication in treating alcohol addiction, particularly in patients who are not eligible for any other treatments due to various health issues.

The present study describes the subjective and behavioral characteristics of 1P-LSD compared to lysergamide, using various pharmacological and analytical methods. This includes an experimental session using a selective serotonin reuptake inhibitor (SSRI) in subjects who were unable to obtain enough serotonin in their plasma using repeated injections of lysergamide. The SSRI was effective in reversing the blocked transmitter function, preventing the transmission of signals between neurons. The researchers showed that this treatment restores levels of serotonin in the brain. The results imply that the efficacy of 1P-LSD as a psychoactive substance can be restored by increasing the amount of serotonin in the brain, similar to the effects of conventional lysergamide (1).


Lysergamides are not just any acid; they are acids that digest and metabolize other chemicals. The body has a wide range of Lysergamides, which also break down vitamin B complex and other chemicals such as niacin, pantothenic acid, norepinephrine, hydrocodone, and serotonin, as well as several other nutrients such as theophylline, thioctic acid, and several others. Because of the diverse nature of Lysergamides, a wide variety of drugs that are metabolic or acid-base in nature are therefore classed as alkaloids, including l-tryptophan and ephedrine (2).

According to the present study, 1P-LSD is more potent than lysergamide and is capable of producing immediate and profound amnesia, unlike lysergamide. Compared to lysergamide, 1P-LSD does not react to external stimuli and produces no symptoms at the beginning of its administration. It produces no signs or feelings of euphoria, affection, or confidence. In addition, 1P-LSD displays signs of being rapidly addictive, with its highly dangerous potential for abuse and dependence. Also, compared to other psychoactive substances, it displays greater potentiation and increases in the intensity of the out-of-sleep feeling (3).

Unlike other serotonergic hallucinogen (5-HT2A) medications, 1P-LSD produces only short-lasting effects. However, some people have reported feeling the effects of this drug for up to a month at a time, even if they were not on medication during the period. Long-term treatment with 1P-LSD is not recommended, as the patient may become dependent on the drug and cease to take it if the dosage is reduced. Also, since the long-lasting effects of this drug are only observed in people who are exposed to it for months, it can be said that the drug is not very habit-forming. So far, there is no evidence that proves 1P-LSD is a cause for addiction or dependence (4).

Source and Formulation of 1P LSD

Acid from pine bark is the source of 1P-LSD. It is usually made in the lab by dissolving a glycoside called glycoside in a carrier solution, then letting it evaporate into a solid solution. The solid is then filtered and injected into the animal’s ears. After a couple of days, the blotter takes on a color similar to that of urine. Because it is so highly concentrated, it can take up to three weeks for a blotter to be sufficiently active to produce the desired results in humans (5).

The blotter is manufactured from pure lysergamide hydrochloride, which is itself a highly specific acid. It is produced as a byproduct of the process of making serine, a natural amino acid, a precursor of many medicines.

This is why blotter paper is used for the administration of this drug. To make it easier to handle, powdered blotter paper is used for injection. A 1P-LSD is given in a single injection of the appropriate amount of powder or liquid, under normal circumstances. Most doctors prefer to use powdered blotter paper rather than the liquid kind because the reaction between the 1P-LSD and the blotter paper is much slower than that between the drug and the liquid.

More About LSD

One of lysergic acid diethylamides’ unique characteristics is that it is produced only by living things. Humans, lizards, birds, insects, and fungus all contain LSD. It can therefore be said that, in addition to being a very powerful psychoactive substance, LSD also has non-psychoactive uses. Among these uses is as a natural antidepressant. The most recent studies on this find that it can reduce anxiety, improve memory, improve mood and reduce pain (6).

In the past, lysergic acid diethylamides were mainly used as a tranquilizer or sedative in scientific and medical research. Because this substance also produces a considerable amount of serotonin, it was considered as an effective treatment for depression, obsessive-compulsive disorders, anxiety, schizophrenia, mania, psychosis, and phobias. It was also used for treating panic attacks, to relax frayed nerves, to increase alertness, and to calm allergic reactions. However, in the last few decades, the medical profession has concluded that it is not only suitable as a mild tranquilizer but can also be used as an efficient treatment for patients with more serious psychological disorders, including major depression, post-traumatic stress disorder, bi-polar disorder, and eating disorders.

The discovery of lysergic acid diethylamide (LSD) and the subsequent medical and psychiatric treatments based on it have provided an important breakthrough in the field of psychiatric medications. The first group of psychiatrists who made this discovery were involved in the study of behavior and cognitive processes in rodents, mainly through the use of intravenous solutions of lysergic acid diethylamide. During this study, it was found that chronic patients suffering from obsessive-compulsive disorders, who were under constant surveillance by doctors, responded remarkably well to intravenous LSD. These results paved the way for the further study of psychedelic drugs for mental disorders. Later studies revealed that the same properties that make these substances useful for obsessive-compulsive disorders can also be useful in the treatment of other psychological conditions like depression and schizophrenia.


Several types of experiments have been performed on animals in order to find out if these compounds can be used in treating some of the more serious psychological conditions. For example, one group of scientists from the University of California at Riverside succeeded in finding out that mice can develop an addiction to phenethylamine (a precursor of many recreational drugs including ecstasy) when given repeated doses. Others in this same group found out that mice lacking the enzyme amyloid peptides (Aph) can develop severe memory loss and other mental disorders. Scientists are still looking for more specific effects of these lysergamides, especially as a possible treatment for Alzheimer’s disease, although at the moment all interest is focused on lysergamides as a source of preventative medicine for dementia patients.

If someone suffers from serious depression, they might be prescribed antidepressants, but these drugs are extremely costly, cause severe side effects, and can also lead to rebound insomnia. People in this situation will usually try either LSD or an acid diethylamide, which is a prescription drug that contains an extremely low amount of serotonin. Although serotonin is important in the brain, it is synthesized in the pineal gland. If the brain cannot produce enough of it, the person develops depression. An acid diethylamide is much cheaper and does not have serious side effects.