Tryptamines are actually a family of drugs that are used as medicines in a few countries. The name is derived from the word tryptone, which means sweet-smelling, and it was originally found in Peru.
Although Tryptamines have not been scientifically proven to have an influence on sleep and related issues, their effects on various systems and bodies have been demonstrated in various animal and human research. It has been shown that Tryptamines can increase alertness and attention, reduce fatigue and increase energy levels as well as improving mood and memory in laboratory rats and mice. Some of these compounds also appear to increase the levels of serotonin in the brain, which has an impact on the ability of the brain to regulate mood and alleviate symptoms of depression. This evidence is significant because it indicates that Tryptamines have a potential benefit as a natural alternative to other substances used in treating sleep disorders (1).
Substituted tryptamines are also called serotonin analogs. The chemical structures of serotonin and tryptamine have been very similar, and through the years they have developed into two distinct and popular neurotransmitters (2). The serotonin analogs act like neurotransmitters, while the tryptamines act as appetite suppressants. Tryptamines are closely related to amphetamines and cocaine but were until recently the least known of all substances which produce the euphoric feelings people associate with in rave parties .
Melatonin is also an essential tryptamine present as a neurotransmitter in the brain. This tryptamine is a hormone that regulates sleep and wake cycles. Melatonin is known to increase brain sensitivity and is used as an anti-depressant. It has also been found to lower blood pressure and is a powerful natural stimulation of the nervous system. Serotonin and melatonin are related, and the tryptamines have been used widely as a natural alternative to prescription drugs (3).
Some tryptamines act in the body in much the same way as do melatonin and serotonin. They are able to modify the actions of serotonin and melatonin, allowing them to be more efficient at enhancing the moods people experience. Many people who take these in conjunction with other drugs like melatonin find that their feelings of happiness and joy return almost immediately. Tryptamines are particularly effective as stimulants, increasing the intensity and frequency of sexual intercourse
What are Tryptamines Made of?
Tryptamines are made from a number of different chemicals including lysine, tryptophan amino acids, epinephrine, and many others. There are two basic types of tryptamines; alkaloids and lysergic acid. All tryptamines share the common features of being enmeshed in a complex structure. Enmeshed within them are numerous lysergic acid receptors, which allow tryptophan to bind with serotonin and melatonin and send a powerful signal between the brain and the rest of the nervous system.
Tryptamines and Tryptophans
Most Tryptamines are derived from Tryptophan, which is a protein found in both plants and animals (4). When Tryptophan is broken down, it releases a series of amino acids that are then used as neurotransmitters by neurons within the body. There are several tryptamine analogs with different molecular structures that share a common structural element of a tryptamine ring and are therefore commonly referred to as Tryptamines. In most cases, tryptamines consist of three amino acid residues bound together by an N-type amine, which is a type of amino acid. A tryptamine ring is made up of one hydrogen atom and a single value group, while its side chain consists of one amino acid, two arginine atoms, and one methyl group.
Tryptamines and the Stimulant Effect for ADHD
Because tryptamines can affect the functions of both melatonin and serotonin, they are sometimes used in conjunction with other drugs like Ritalin and Adderall. However, many researchers believe that tryptophan and serotonin analogs may have a much greater influence on ADHD behavior than was previously thought. Tryptamines can work by binding to and activating serotonin, allowing the levels of serotonin in the brain to increase. Greater levels of serotonin in the brain are believed to enhance alertness and attention, while less levels of it cause feelings of depression and anxiety. Tryptamines have also been found to improve concentration and improve memory in people with ADHD (5).
While most tryptamines are not manufactured or consumed in the typical diet, there are a handful of natural tryptamines that have become available through dietary supplements. Some of these herbal dietary supplements are derived from naturally occurring plant sources like U.S. corn, hemp, and ginseng. Many of these supplements contain tryptophan, which is a component of many protein-based foods such as meats, eggs, and dairy products. While tryptophan is a component of many amino acids, it is not produced naturally in food and must be added as an ingredient through supplementation (6).
While Tryptamines have been studied extensively in both the scientific and medical communities, there is still much more that is still not known about their structure, function, and effects. The main remaining mystery is how the brain decides that tryptamine will be effective, how they work, and how they can be delivered into the brain. Currently, there is only one well-established way of delivery, which is through the use of oral medications. However, there is hope as new research is being conducted to discover other types of Tryptamines and discover how they might function in the human body.
Tryptamines function as neurotransmitters, affecting the brain through their impact on serotonin receptors in the synapse. Although tryptamine compounds have been studied extensively in recent years, only a few of them have been found to be effective in treating ADHD. In one study that examined the efficacy of tryptamine versus placebo in children with ADHD, parents of children with the disorder were given information about the tryptamine-elimine complex (which was later deemed successful in treating ADHD), but were not told that it contained tryptamine, nor was there any indication that the child could take the supplement on his own. The study’s authors concluded that the results of this study demonstrate the importance of trying to find alternative ways of treating ADHD rather than depending purely on stimulant medications.