Benzofurans are psychotropic drugs with a number of important roles in the nervous system and also empathogenic¬†psychoactive compounds. Benzofurans are the most abundant substituted phenethylamine which are present in the body. 6-APB, its derivatives, and other substances are sometimes referred to as “benzofurans”. 6-APB can have toxic effects and the related symptoms at low dosages can also lead to severe health problems. Therefore, people who are using benzofurans should know about the possible dangers and symptoms of the drugs (1).

Adverse Reactions


The first adverse reaction of 6-APB was observed in patients who were administered the drug during emergency situations. Some of these patients developed signs of nervous system disorder. Patients with cardiopulmonary conditions and heart disease were also exposed to this substance. Subsequently, the frequency of such occurrences decreased significantly.

In addition, it is known that Benzo Furan has neurodegenerative side effects. It is believed that these side effects can result in Parkinson’s disease. The decrease in motor skills is reported as a cognitive decline or a slowing down of movement. Some patients also reported the inability to speak fluently.

There was also a decrease in the levels of cerebral blood flow. This is because of the lack of N-methyl-D-aspartic acid (N-methyl D-Aspartic Acid). Neurofibrillary tangles developed on the myelin sheath around the cerebellum. These tangles blocked the communication between brain cells and the nervous system.

Other Effects

Benzo Furan has also been shown to increase the level of plasma triglycerides in human plasma. However, the mechanism involved is not known clearly. The increase in plasma triglycerides is considered as one of its side effects. Triglycerides are fats that are stored in the body.

Some of the patients who had taken this drug showed significant improvement in depression. However, there are also reports of anxiety, irritability, and insomnia. Other drug users have suffered from nausea and vomiting. One of its major allergens is the peanut. This drug contains trace amounts of peanuts. The possibility that the peanuts might trigger an allergic reaction has thus been raised.

If you have an existing medical condition, you should consult your doctor before taking this drug. Individuals with pre-existing liver and kidney disease are restricted to non-drug therapies. Benzofurans cannot be mixed with other anti-depressants. You should not take these drugs if you suffer from seizures, heart or liver disease, or if you are pregnant.



Benzofuran can be taken once per day for medicinal purposes and under prescription for certain patients. Like any other anti-depressant drug, some patients experience headaches, nausea, dizziness, and a few changes in mood. Most patients who experienced these side effects said that they disappeared after their medication was stopped. For women, the possible side effects include breast tenderness, headaches, facial skin changes, and breast enlargement. Some patients, however, have increased heart rate, nervousness, and sweating.

It is advised to contact your physician if you experience these symptoms after taking the drug for six weeks or more. Your doctor will tell you if you are a suitable candidate for this drug or not. There have been reports that some patients have tardive dyskinesia, a condition characterized by muscle spasms. However, these patients do not respond well to benzodiazepines.

Some people, even after taking these drugs for several months, develop withdrawal symptoms. These include restlessness, depression, irritability, insomnia, dizziness, anxiety, and frequent urination. Some patients have reported problems with memory loss, nightmares, and feelings of panic. There are also reports of sexual dysfunction and impotence in men.

It is important that you ask your doctor about any other possible side effects or concerns that you may have about the drug before taking it. You should not stop taking Benzo Furan without informing your doctor. The drug can be habit-forming if you stop taking it suddenly. Many patients become dependent on this medication and cannot function without it for a long period of time.

If you are pregnant or breastfeeding, there could be a risk of birth defects. You should notify your doctor if you are taking any drugs (prescription or illegal) such as antibiotics, tranquilizers, alcohol, or any other sedatives. Before taking Benzo Furan, you should talk to your doctor about any health problems you have, any allergies you may have and any medications you are currently taking. For more information, talk to your pharmacist.