Description
Ro5-4864, 4′-chlorodiazepam
Product information
IUPAC-name 7-Chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
Synonyms Ro5-4864, 4′-chlorodiazepam
Formal name 7-Chloro-5-(4-chlorophenyl)-1-methyl-3H-1,4-benzodiazepin-2-one
Cas number 14439-61-3
Formula C16H12Cl2N2O
Molar Mass 319.185 g·mol−1
Purity 99.0 % min.
Formulations A neat solid, Powder
Solubility
- DMF: 20mg/mL
- DMSO: 10mg/mL
- Ethanol: 20mg/mL
- PBS (pH 7.2): 2mg/mL
Ro5-4864, 4′-chlorodiazepam
A derivative of diazepam known as Ro5-4864 is a drug that is used to treat anxiety and other related disorders. Unlike other similar drugs, it does not have the usual effects of a benzodiazepine. It also has anxiogenic and convulsant effect. The drug was eventually renamed to 18kDa after it was discovered to be a potent receptor for the benzodiazepine receptor.
Despite its side effects, Ro5-4864 has been known to be neuroprotective. It has been used in studies on the role of the TSPO protein in the development of neurotoxic effects. In vitro studies and animal models suggest that the drug could potentially be used as an anti-cancer drug and an antidepressant.
The toxicological and physiological properties of this compound has not been analyzed. Usage of this Chemical should be for research and forensic purposes only.
WARNING This product is not for human or veterinary use.
This product is only available to persons of 21 years old and above.
Hazard statement(s)
| H302 | Harmful if swallowed |
| H315 | Causes skin irritation |
| H319 | Causes serious eye irritation |
| H332 | Harmful if inhaled |
| H335 | cause respiratory irritation |
| H336 | cause drowsiness or dizziness |
| Precautionary statement(s) | |
| P264 | Wash hands thoroughly after handling |
| P280 | protective gloves/protective clothing/eye protection/face protection |
| P305 + P351 + P338 | IF IN EYES: Rinse cautiously with for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| P337 + P313 | If eye irritation persists: Get medical advice/attention |
| P261 | Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray |
| P271 | Use only outdoors or in a well-ventilated area |
| P304 + P340 | IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing |
| P312 | Call a POISON CENTER or doctor/physician if you feel unwell |
| P403 + P233 | Store in a well-ventilated place. Keep container tightly closed |
| P405 | Store locked up |
| P501 | Dispose of contents/container to a licensed disposal company |
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