Diclazepam which is also known as chlorodiazepam belongs to the benzodiazepines family, with a long history of medical use in the US. Ativan, Xanax, and Klonopin are the well-known benzodiazepines, while Diclazepam belongs to the azapironium aluminum nitrate family. It was first developed as a tranquilizer for patients suffering from depression and anxiety. Recently, it has been used to relieve muscle spasms associated with chemotherapy, epilepsy, meningitis, etc (1).
Diclazepam also belongs to the azapironium aluminum nitrate family, which includes other common benzodiazepines such as Lorazepam, Valium, and Ativan. Unlike many benzodiazepine drugs, Diclazepam does not undergo metabolic degradation during the metabolism process. Because of this, Diclazepam can maintain its effectiveness even in people who are malnourished or have low protein nutritional status. While being metabolized, the drug’s active ingredients are stored in the various tissues where they act on fatigue, weakness, anxiety, and insomnia (2).
Components of Diclazepam
The main components of diclazepam are flavonoids, terpenoids, and amines. The flavonoids are represented by oxproic acid, ergosterol, quercetrin, and procyanidins. The common mode of action of these compounds is to reduce hyperactivity and restlessness in patients taking the drug. Some of the most common amines include dextroamphetamine, dextroflavinoids, mepropranol, quercetrin, tricyclic triterpenoids, and bromelain. It is believed that the efficacy of this drug is related to the ability of some of its metabolizers to form benzodiazepines that may have multiple effects on the body.
The Long-Term Use of Diclazepam
Based on studies, much evidence was found concerning the long-term use of diclazepam and its potential for causing the liver to build up a higher level of cytosolic acid than is needed for normal function. These measurements were made using a type of enzyme-linked immunosorbent assay (ELISA, EIA). Based on the results of this study, it was concluded that low to lower concentrations of cytosolic acid are produced by lorazepam in patients taking a high dose of the drug.
A major problem with benzodiazepines, including diclazepam and lorazepam, is that they are very difficult to metabolize in most people. This is because many of the benzodiazepines have structural features that make them more difficult for the system to convert into its active form. As a result, the majority of patients are unable to maintain their prescription dosage of these benzodiazepines over the long-run.
One way that researchers have sought to address this issue is to look for a pharmaceutical that could replace the effectiveness of these compounds. There are a number of these substances in development. Currently, one such substance is known as alprozalam. Preliminary studies have shown that alprozalam, which is in phase II clinical trials, is effective in alleviating the symptoms of anxiety and inducing sleep in patients.
Request for further research on Diclazepam
Based on the above information, it seems clear that there is a very limited amount of research chemicals currently available that could effectively replace the current benzodiazepines. Therefore, if you suffer from insomnia, your only viable option at this time appears to be either doxycycline or alprozalam. Both of these substances have been demonstrated to produce a reduction in symptoms during the initial short-term use, which leads some medical professionals to believe that long-term use may be necessary for some patients. However, there are still reports of people experiencing side effects from doxycycline and alprozalam. For this reason, both of these compounds are not currently approved by the FDA for use as benzodiazepines.
Based on the above information, it appears clear that there are limited, though legitimate, sources for diclazepam replacement at this time. The best choice at this point would seem to be to purchase a low dosage self-medication test kit. By combining the precise strengths of these two substances, patients can effectively reduce their current dosage and avoid the potentially harmful side effects that are associated with the long-term use of benzodiazepines. With a properly conducted self-test, no patient should suffer from any long-term effects from taking these medications.
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