Phenylethylamine is a chemical substance that naturally exists in the human body. It is produced by various species in humans, plants, and in the kingdoms of animals. It is also manufactured in the laboratory. It acts as a central nervous system stimulant in humans. As a central nervous system stimulant, phenethylamine is used to treat depression and many other mental illnesses. Most importantly, it is used for weight loss, sports performance, and improving mood and concentration. More research needs to be done to support these claims (1)(2)(3).


Phenethylamines belong to a broad category of psychoactive substances with a long history of licit and illicit use. The licit use of phenethylamine has been for spiritual and medical purposes while the illicit use has been more for recreational purposes. As phenethylamines gets popular, young individuals have been catching fun with these compounds in rave and slub environments. The easy access of phenethylamine today has lead to an increase in its abuse by youths. This has been a major issue and has created mixed feelings towards Phenethylamines and got the attention of the authorities who are fighting to make sure phenethylamine is used the right way and for the right purpose (4).

International Concerns of Phenethylamine Towards Abuse

For a fact, international concerns for phenethylamine have increased and in the UK phenethylamine was outlawed in 2002 and is now considered as a Class A (Schedule I) drug. In the US, the DEA considers phenethylamines as a Schedule I drug and not all. Some phenethylamines still remain legal to use medically. To answer the question, is phenethylamine illegal? under the ASCS Act (Analogue Statue of the Controlled Substance), it is practically illegal to traffic any compound chemically analogous to phenethylamines (5).

Beneficial Usage of Phenethylamine

¬†According to the FDA, it is a “food supplement” and the agency considers it safe for human consumption. Taking phenethylamine as a supplement can help those who cannot produce enough phenethylamine naturally. Still, some experts have raised questions about the safety of this powerful stimulant.


The question of whether or not phenethylamine is legal has been addressed many times, and the answer isn’t very clear. Most people can buy it off the shelves without any health risks. However, there are some severe side effects associated with the use of this chemical, including nervousness, anxiety, panic attacks, depression, agitation, tremors, nausea, vomiting, seizures, coma, and even death. With this, many are for the control of phenethylamine.

Reasons Pushing Towards the Control of Phenethylamine

The above concerns explain the one reason why health care providers usually advise against the use of many diet aids, including ephedra and ephedrine, which are believed to be effective in boosting energy and helping people lose weight. If you decide to use phenethylamine as a pick-me-up, as many consider it to be, you need to make sure that you are aware of its possible side effects, which are pretty severe. It is probably best to avoid it altogether. Yet, there are situations where it might be appropriate to use it, such as: if you suffer from epilepsy, a seizure disorder, depression, diabetes, dementia, mania, or hyperthyroidism; if you are pregnant, expecting, or breastfeeding; if you suffer from cancer or other serious medical conditions. If you take prescription medications, especially stimulants, please consult your physician before adding phenethylamine to your regimen.

The second reason why it is not likely safe to combine phenethylamine with other drugs like tryptamines is because most people who suffer from Phenylpropanism do not have an addiction problem. They simply find that they enjoy the immediate results of the drug. That is why the two substances are often found together in the illegal phenethylamine market. Although recreational use of these substances is not uncommon, the recreational use of these two substances is considered to be highly dangerous and could cause severe health problems. The side effects of phenylethylamine can range from confusion and dizziness, to severe depression, delusions and hallucinations, and, in extreme cases, suicide. Because of this, it is illegal to sell, distribute, and use phenethylamine under any circumstances.

Usage of Phenethylamine with other Drugs

While it is true that many health risks exist when it comes to combining phenylethylamine and other drugs, it is probably fair to say that the greatest danger of phenethylamine is when it is used in isolation. When taken alone, it causes very little change in blood flow and blood pressure, but when it is consumed in extremely large doses, it creates a wide range of adverse effects on almost every system in the body. Because of this, it is important that anyone looking to purchase supplements containing phenylethylamine should get good, reliable safety data and use them accordingly. Any supplement containing this compound must be accompanied by a full list of ingredients, along with a statement from the manufacturer that says that the combination of this compound with other compounds is not safe and will lead to severe, life-threatening side effects if such combinations are done without consulting with a medical professional first. Phenethylamine supplements are still legal in many states, so long as they come with proper warning labels.

Reseach Chemicals

Phenethylamine and Monoamine Oxide.

Monoamine oxidase (MAO) supplements are another popular substance used by depressed patients to try and combat the nasty side effects of phenethylamine. Like most supplements, there is good, reliable information out there concerning the efficacy of these products in helping to treat phenylamine-induced behavior disorders and the like. However, it is also important for anyone considering MAO products to know and understand that even though the substances themselves are relatively safe, any MAO product, even those sold over-the-counter, can produce a dangerous build-up of potentially harmful conditions if used improperly. This includes things like birth defects, liver damage, and depression.

One last condition related to phenylethylamine and MAO is dyme dystrophy, or “white hand”, a rare condition in which the body lacks the proper amount or activity of a specific set of neurotransmitters known as norepinephrine and epinephrine. Because this condition frequently accompanies high levels of anxiety or depression, it can be used to test the effects of low doses of phenethylamine on these neurotransmitters. Unfortunately, much of the evidence surrounding the use of this substance for these purposes comes from the work of autistic individuals, who are most at risk for developing type dystrophy as a result of prolonged phenylamine use. There is, however, sufficient evidence to suggest that there may be some benefit to individuals with other mental disorders, particularly if they exhibit a chronic lack of concentration or poor impulse control. For example, individuals with attention deficit disorder, attention deficit hyperactivity disorder, depression, and other mood disorders have all been shown to be at a higher risk of developing dymestrophy.

If you’re interested in trying out MAO to treat a specific problem, or if you just want to try out some of the benefits of Phenethylamine in general, there are several different types available. The two main MAOs are Isotretinoin and Accutane, which work by reducing the amount of dopamine in your body and preventing it from being metabolized. The most popular MAOI for depression and Alzheimer’s sufferers is hydrochlorthiazide (also known as Glucophage), which is a prescription supplement that is combined with physical therapy in order to reduce and possibly prevent amyloid protein buildup and neurofibrillary tangles. There are also many dietary supplements that contain small amounts of Phenethylamine and other trace amines for the treatment of psychiatric disorders. In the short term, Phenethylamine supplements may be used to increase alertness and concentration, but there is no concrete clinical evidence linking its use to any improvements in depressive or manic episodes or other serious mental health issues.