Phenylethylamine is a chemical substance that naturally exists in the body. It is also manufactured in the laboratory. Phenylethylamine is produced by various species in the human, plant, and animal kingdoms. It acts as a central nervous system stimulant in humans. Phenylethylamine is used for depression, weight loss, sports performance, and to improve mood and concentration. More studies need to be done to support these claims (1).


As a central nervous system Stimulant, Phenethylamine stimulates the body to create some chemicals that may help with depression and other mental illnesses. Taking phenethylamine as a supplement can help those who cannot produce enough phenethylamine naturally. However, using too much of phenethylamine may cause side effects that are known to be similar to those of amphetamine (2)(3).

Phenylethylamine is a neurotransmitter precursor. It is most active in the central nervous system (CNS) and is believed to affect mood and behavior. It is a popular recreational drug, but there is controversy surrounding its safety. It is usually purchased via the Internet and used mostly by adults and can produce serious side effects when abused.

Other Related Compounds

It should be noted that there are currently seven major classes of designer drugs considered similar to phenethylamine: phencyclic amines, cannibinogenic compounds, enkephalins, flavonoid chemicals, neuroleptic substances, tricyclic antidepressants, and reversible amines. Although many of these substances have similar structures to phenethylamine, each class represents a distinct class of substances with unique properties and toxicology. For this reason, it is important to be aware of the contents of a given mixture and determine whether or not it may be abused before purchase.

Phenethylamine Class of the 2C Family

Phenethylamine belongs to the 2C family of antidepressants. It shares its structural base with other substances in a large family of aromatic compounds called the aromatic ligands. This group includes several substances with hallucinogenic properties such as diphenhydramine (DHT), trifluoperazine (TFA), and quetiapine (SQP). However, it isomers of the phenethylamine group are the focus of much research and studies. The two most common chemical neurotransmitters are epinephrine and norepinephrine. The two chemicals stimulate the release of certain neurotransmitters in the brain.


Long-term Use of Phenethylamine.

There have been no published studies concerning the long-term use of phenethylamine, particularly when it is taken in its pure form. It is a very strong designer drug and with very strong effects to the body. A substantial amount of the drug is believed to be found within the brain and liver. There is very limited published literature on the effects of the drug in animals, despite the fact that it has been used for decades in veterinary medicine. This lack of research casts doubt on the effectiveness of the substance in treating canine epilepsy and can lead to dire consequences if it is ingested.

Although there have been some promising results in the use of phenylethylamine derivatives for depression and attention deficit hyperactivity disorder, these effects have not been replicated in clinical trials. There is no current use of this substance in human studies to test for abuse potential. Animal studies have not established any toxic side effects when use is made under the supervision of a veterinarian. Animal studies do indicate that the possible side effects of this chemical in high doses are the same as those of amphetamine.

Currently, the Food and Drug Administration (FDA) has not approved the use of these substances in humans. Because they are still considered illegal substances, there is very little information available on their clinical effects or on their long-term health hazards. Most major cities across the United States, as well as other countries, have many animal poison centers which receive shipments from the pharmaceutical and animal poison industries. Animal poison centers have been known to use these chemicals in euthanasia cases. It is unknown whether these facilities inform the FDA or not about the use of these chemicals.

Research Chemicals

Animal studies involving children, pregnant women, and mentally retarded people have shown that phenethylamine and other related compounds including leachisite and amine are harmful if used at high doses over extended periods of time. People who take these at even low levels over a long period of time can experience multiple symptoms, including anxiety, seizures, hallucinations, hostility, mania, delusions, depression, irritability, agitation, and blushing. People who use Phenethylamine are also at risk for car crashes, possible heart attacks, hypothermia, memory loss, and drug or alcohol addiction. It is believed that some individuals may develop an addiction to Phenethylamine.

Although there is some evidence of the medicinal benefits of Phenethylamine, it should be noted that the medical community has not approved these substances for treating any medical condition. It is believed that further studies must be done before these substances can be approved for treatment. In the meantime, Phenethylamine is a very safe substance with few side effects and very little health risk when used properly. If you are taking one of these substances under careful supervision, there will be very little risk of addiction or other negative health effects. With regular use, Phenethylamine can produce powerful hallucinations which can be beneficial in certain situations, but their real potential uses are still unknown.