Description
LSZ, Lysergic acid 2,4-dimethylazetidide, LA-SS-Az
Product information
IUPAC-name [(6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-yl]-[(2S,4S)-2,4-dimethylazetidin-1-yl]methanone
Synonyms LSZ, Lysergic acid 2,4-dimethylazetidide, LA-SS-Az, Diazedine, Lambda
Formal name [(6aR,9R)-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-yl]-[(2S,4S)-2,4-dimethylazetidin-1-yl]methanone
Cas number 470666-31-0
Formula C21H25N3O
Molar Mass 335.451 g·mol−1
Purity 99.0 % min.
Formulations A neat solid, Powder
Solubility
- DMF: 10 mg/ml
- DMF:PBS (pH 7.2) (1:7): 0.12 mg/ml
- DMSO: 1 mg/ml
- Ethanol: 1 mg/ml
LSZ, Lysergic acid 2,4-dimethylazetidide, LA-SS-Az, Diazedine, Lambda
A class of drugs known as LSD analogue, which is also known as LSZ, was developed by David Nichols and his team at Purdue University. A synthetic LSD-like substance known as 2,4-dimethylazetidide is produced by the lysergamide chemical class. It can produce psychedelic effects when ingested. It was made with the diethylamide group bound into azetidine rings. There are three stereoisomers around this region, and the most potent one is the (S,S,+), which is slightly more potent than LSD in drug discrimination tests.
There have been several reports of illicit laboratories producing lysergic acid 2,4 diethylazetidide. These drugs were reportedly being distributed in liquid form or on blotter paper.
In 2013, LSZ was seen on the UK’s designer chemical and pharmaceutical markets. It then gained widespread popularity through mail-order psychedelic shops in 2012.
Prior to 2012, LSZ had no known human usage. It was first spotted in the UK in 2012 and became popular through a cluster of mail-order novel shops. There have also been various reports of it being produced in illicit laboratories and being distributed in liquid solution or blotter paper.
Although it is not considered to be addictive, it can cause severe psychological reactions, such as paranoia and anxiety, especially among those with mental disorders. It is important to avoid using this substance in combination with other drugs or in combination with other harmful substances.
Chemistry
Lysergic acid 2,4 diethylazidide, or LSZ, is a semi-synthetic alkaloid of lysergamide. It has a core structure that is composed of amine functional groups bound to the RN chemical structure. This polycyclic structure has multiple phenethylamine and tryptamine groups.
The structure is composed of a bicyclic hexahydroindole and a bicyclic quinoline group. When the carbon 8 of the quinoline reaches the point where an amide group is bound, it forms a 2,4 dimethylazetidide compound. LSZ is then substituted with a methyl group.
There are three stereoisomers around the azettidine ring, and the most active one is the isomer of LSD. It is more potent than LSD in drug discrimination tests.
Pharmacology
The drug LSZ is a partial agonist of 5-HT2A. It is believed that the effects of this drug can trigger a psychedelic experience. However, the exact mechanism by which this happens remains unclear.
The toxicological and physiological properties of this compound has not been analyzed. Usage of this Chemical should be for research and forensic purposes only.
WARNING This product is not for human or veterinary use.
This product is only available to persons of 21 years old and above.
Hazard statement(s)
H302 | Harmful if swallowed |
H315 | Causes skin irritation |
H319 | Causes serious eye irritation |
H332 | Harmful if inhaled |
H335 | cause respiratory irritation |
H336 | cause drowsiness or dizziness |
Precautionary statement(s) | |
P264 | Wash hands thoroughly after handling |
P280 | protective gloves/protective clothing/eye protection/face protection |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P337 + P313 | If eye irritation persists: Get medical advice/attention |
P261 | Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray |
P271 | Use only outdoors or in a well-ventilated area |
P304 + P340 | IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing |
P312 | Call a POISON CENTER or doctor/physician if you feel unwell |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed |
P405 | Store locked up |
P501 | Dispose of contents/container to a licensed disposal company |
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