Description
mescaline-NBOMe, 345-NBOMe
Product information
IUPAC-name N-(2-Methoxybenzyl)-2-(3,4,5-trimethoxyphenyl)ethan-1-amine
Synonyms NBOMe-mescaline, mescaline-NBOMe, 345-NBOMe
Formal name 3,4,5-trimethoxy-N-[(2-methoxyphenyl)methyl]-benzeneethanamine, monohydrochloride
Cas number NA
Formula C19H25NO4 • HCl
Formula Weight 367.9
Purity 99.0 % min.
Formulations A neat solid, Powder
Solubility
- DMF: 10 mg/ml
- DMSO: 20 mg/ml
- Ethanol: 10 mg/ml
- PBS (pH 7.2): 5 mg/ml
NBOMe-mescaline, mescaline-NBOMe, N-(2-methoxybenzyl)-3,4,5-trimethoxyphenethylamine; 2-(3,4,5-trimethoxyphenyl)-N-[(2-methoxyphenyl)methyl]ethanamine; 3,4,5-Trimethoxy-N-(2-methoxybenzyl)phenethylamine,
NBOMe mescaline, mescaline NBOMe, 345 NBOMe
Mescaline-NBOme is a synthetic phenethylamine that can be used as a partial agonist of the serotonin receptors. It was originally reported as being around 50 nM Ki. However, modern methods have shown that it can be produced at concentrations of around 140 nM and 640 nM at 5-HT2C and 5-HT2.
The two compounds, NBOMe-mescaline and NBOMe-escaline, were first reported in 1999 after research at Free University Berlin revealed their activity as partial agonists of the 5-HT2A receptors. In 2008, it was revealed that individuals had been self-administered NBOMe-mescaline, which was a psychedelic drug. It was eventually made available to the market in 2010.
Chemistry
The solubility of the hydrochloride salt in PBS is approximately 5%. In ethanol, DMF, and DMSO, it is around 10%.
Mescaline and 2-methylbenzaldehyde can be used to produce NBOMe-memo-mescaline, which can be done by reductive alkylation. This process can be performed stepwise, such as making the imine, reducing it with sodium borohydride or directly reacting it with sodium triacetoxy borohydride. An alternative method is also available, which eliminates the need for mescaline as an illicit precursor. This process involves a one-pot reaction of 3,4,5-trimethoxyphenacetonitrile and lithium aluminum hydrride.
The toxicological and physiological properties of this compound has not been analyzed. Usage of this Chemical should be for research and forensic purposes only.
WARNING This product is not for human or veterinary use.
This product is only available to persons of 21 years old and above.
Hazard statement(s)
| H302 | Harmful if swallowed |
| H315 | Causes skin irritation |
| H319 | Causes serious eye irritation |
| H332 | Harmful if inhaled |
| H335 | cause respiratory irritation |
| H336 | cause drowsiness or dizziness |
| Precautionary statement(s) | |
| P264 | Wash hands thoroughly after handling |
| P280 | protective gloves/protective clothing/eye protection/face protection |
| P305 + P351 + P338 | IF IN EYES: Rinse cautiously with for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| P337 + P313 | If eye irritation persists: Get medical advice/attention |
| P261 | Avoid breathing dust/ fume/ gas/ mist/ vapors/ spray |
| P271 | Use only outdoors or in a well-ventilated area |
| P304 + P340 | IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing |
| P312 | Call a POISON CENTER or doctor/physician if you feel unwell |
| P403 + P233 | Store in a well-ventilated place. Keep container tightly closed |
| P405 | Store locked up |
| P501 | Dispose of contents/container to a licensed disposal company |
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